Jessenius Faculty of Medicine
in Martin
Comenius University in Bratislava

Graduate study

Subject Molecular biology 3. year general medicine, winter semester 2020, academic year 2020/2021 


Subject description:

The graduate should acquire basic overview about molecular biology  in medicine,  knowledge concerning application of the methods of molecular biology in medicine general and in personalized medicine particularly, working with genomic internet brosers, understanding the basic principles of molecular diagnostics,  precision  medicine and interpretation of the results of the molecular-genetic examinations using databases.

Literature: Study material is uploaded in MS Teams

Recommended textbooks and databases:

T . Strachan, J. Goodship, P. Chinnery: Genetics and Genomics in Medicine, 2015 by Garland Science, Taylor and Francis Group, NewYork and London (selected chapters) ISBN 978-0-8153-4480-3 - Online Medelian Inheritance in Man

Prerequisite: Good background knowledge of basic principles of molecular biology and classical genetics is expected  

Lectures – Friday 2 PM - 3:45 PM  online   MS Teams Molecular Biology WInter 2020 Lecture

Classes - MS Teams and Department of Molecular Biology and Genomics, Mala hora 4C, 4th. fluor  

1.week (Sept. 18th)

The human genome project, human genome organization, variations in human genome, internet genomic browsers, DNA sequence databases, databases of genes

2.week (Sept. 25th)

Methods in molecular biology I   

3. week (Oct. 2th)

Molecular biology of the genes  and  disease-causing variants.   

4.week (Oct. 9th)

Clinical application of molecular biology  

5. week (Oct. 16th)


LECTURE Methods in molecular biology II

6. week (Oct. 23rd)


LECTURE Molecular biology of Cancer

28.9.-9.10.2020 (week 3 and 4)

In silico gene annotation and PCR design, Sanger Sequencing, preparation of the first part of the project.  

 12.10.-23.10.2019 (week 5 and 6)

In silico variant detection and interpretation , preparation of the second part of the project.  .      

 26.10.-6.11.2019 (weeks 7 and 8)

 Droplet digital PCR  in cancer diagnostic, PCR in prenatal testing. Preparation of the third part of the project.


9.11-20.11.2019 (weeks 9 and 10)

Project presentations and discussion 

Examples of Clinical Applications of Molecular Biology, working with interactive electronic texbook


Attendance and participation:

Your attendance in classes is essential for 100%.  For serious reasons it is possible to excuse 20%.

Grading: Your final grade from the course will be calculated as follows – 100% attendance classes plus



Online test  

 Class  1-3 results each 5 %


40 %

45 %

 15 %




A/1 grade = 91-100 points         C/2 grade =73-80 points             E/3 grade =60-65 points


B/1,5 grade = 81-90 points          D/2,5 grade =66-72 points           FX grade=less than 60 points