Research

Since 2000, scientific research activities are focused on the field of experimental oncology, cytogenetics, and immunohistochemistry.

1. Chemoprevention of experimental mammary carcinogenesis in rats with pleiotropic active agents - statins, retinoids, nonsteroidal anti-inflammatory drugs, melatonin, recently with herbal drugs, and also testing antineoplastic effects of those substances in vitro.
2. Evaluation of chromosomal damage due to genotoxic substances present in the environment and working environment and relationships between the occurrence of these chromosomal damage and gene polymorphisms of xenobiotic metabolism and DNA repair genes in cooperation with the Department of Occupational Medicine and Toxicology JFMED CU and University Hospital Martin and the Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague.
3. Study of relations between chromosomal damage and the incidence of colorectal and lung cancer in collaboration with the Institute of Experimental Medicine, Academy of Sciences of the Czech Republic Prague and Institute of Medical Biochemistry JFMED CU Martin.
4. Relationship of polymorphisms and mutations tumour suppressive genes p53, BRCA1 and BRCA2 with cancer in cooperation with the Institute of Medical Biochemistry JFMED CU Martin