Science and Research
Research activities of the clinic:
a) Main focus:
1. The study of maternal and fetal hemodynamics using ultrasonography
2. Study of influencing the growth of uterine myomas embolization of uterine arteries
3. Preventive and screening measures for malignant diseases of the breast and female genital
4. Prenatal genetic diagnosis (invasive / noninvasive form)
5. Detection of sentinel lymph node in breast and cervical cancer
6. The use of molecular biology in the diagnosis of breast cancer and internal genitalia
7. The use of molecular biology in the diagnosis of pregnancy pathologies and developmental disorders of the fetus
8. Early detection of fetal distress during pregnancy and childbirth
9. The study of hypertensive disorders in pregnancy
b) Grant solved at the workplace: - completed + principal investigator:
- Prof. Ján Danko, M.D., PhD.
1) Grant the Ministry of Health: 2007/60-MFN-03: Early prediction of preeclampsia.
2) Grant VEGA 1/3374/06: the importance of setting steroid receptor expression and aromatase gene mRNA and the change in the estrogen metabolism encoded by the gene CYP19 with endometriosis.
3) Grant VEGA 1/0077/08: Early prediction of preeclampsia using markers of endothelial dysfunction and Dopler ultrasound changes of uteroplacental and fetal circulation.
4) Grunenthal Grant 2008: Randomized, double blind, paralied-arm, placebo-and comparator-controlled trial of the Efficacy and Safety of Multiple Doses of immediate-release (IR) for CG5503 postoperative pain following abdominal hysterectomy.
5) Medi-Nova AG 2005: Multi-center open, uncontrolled study to investigate the efficacy and safety of the oral contraceptive SH T 186 D containing 0.02 mg ethinylestradiol-B-cyclodextrin clathrate and 3 mg drospirenone in a 24-day regimen the 13 cycles in 1010 healthy female.
- Assoc. prof. Pavol Žúbor, M.D., PhD.
1) University grant 22/2004: Population focus randomized controlled study supported [Ile (655) Val] polymorphisms of HER-2 gene and the risk of mammary cancer in a population of Slovak women
2) University grant 46/2005: Polymorphism of genes CYP 17, CYP 19 cytochrome P450, CYP 1B1 and COMT modulating steroid metabolism and estrogen receptor activity in association with the regulatory effect of p21 and p53 genes in the pathogenesis of endometrial cancer I and II types. Predictive significance of the finding in the prevention of cancer.
3) University grant 252/2006: The basal myoepithelial differentiation in breast cancer
4) Grant the Ministry of Health: 2005/14-MFN-06: Create and implement an optimal diagnostic model development for early detection of malignant breast disease, body and cervix
5) Grant VEGA 1/3379/06: Determined Examination of the gene HER-2 status in the management of prevention, diagnosis and treatment of invasive mammary carcinoma in women
6) Grant VEGA 1/0069/09: Early detection of invasive breast cancer by using markers of cellular proliferation, apoptosis and hypoxic tissue damage.
- Assoc. prof. Jozef Višňovský, M.D., PhD.
1) Grant VEGA 1/1188/04: Oviduct smooth muscle contractility and the possibility of a pharmacological effect.
2) Grant JFM CU: I-4/2002: The contribution of electrocardiography in assessing the functional status of the fetus.
3) Grant JFM CU: I-6/2002: Doppler sonography / Doppler ultrasound investigation of the circulation in I. trimester of pregnancy.
- Assoc. prof. Stanislav Tomáš, M.D., PhD.
1) Grant JFM CU: Impact of EDA in oxygenation and metabolic status of the fetus and newborn.
2) Grant JFM CU: I-5/2002: Importance of biosensors in assessing the current status of the fetus during labor.
- Karol Dókuš, M.D., PhD.
1) University grant 188/2003: Detection of intrapartum fetal hypoxia: the contribution of intrapartum pulse oximetry for clinical practice.
2) University grant 47/2004: Detection of intrapartum fetal hypoxia: the current options.
3) Grant APVT: 20-033104: Current possibilities and optimization procedures in the detection of hypoxia to the fetus during pregnancy and childbirth.
- Silvester Galo, M.D., PhD.
1) University grant: Endometriosis - early diagnosis, the effect of medication and surgical treatment.
- Terézia Paštéková, M.D., PhD.
1) University grant 195/2003: Doppler sonography / Doppler ultrasound investigation of the circulation in early pregnancy.
- Imrich Žigo, M.D., PhD.
1) Grant VEGA 1/3384/06: Genetic polymorphisms in vasoactive genes and preeclampsia pathogenesis of hypertension in pregnancy.
- Marianna Grúberová, M.D., PhD.
1) University grant 40/2004: The importance of lactate in assessing the current status of the fetus during labor.
- František Janíček, M.D., PhD.
1) University grant 80/2007: Effects on contractility of pregnant myometrium by inhibitors of PDE4 and PDE5, and without a B2-agonist activity.
- Zuzana Martinková, M.D., PhD.
1) University grant 42/2004: The importance of fetal ECG monitoring in a functional state of the fetus during labor.
- Jana Gabajová, M.D.
1) University grant 262/2006: Cytochrome P 450 1A1, 1B1, and VEGF COMT gene polymorphism and risk of endometrial cancer.
- Kristína Biskupská Boďová, M.D., PhD.
1) University grant 446/2008: Changes in soluble trombomodulin I and PA-1 and Doppler sonography / Doppler ultrasound parameters in women with preeclampsia and their use in the early prediction of preeclampsia.
2) University grant 34/2009: Changes in soluble trombomodulin I and PA-1 and Doppler sonography / Doppler ultrasound parameters in women with preeclampsia and their use in the early prediction of preeclampsia - cont.
- Martina Cuľbová, M.D., PhD.
1) University grant 420/2008: a tumor suppressor gene hypermethylation as a new marker for early diagnosis of ovarian cancer.
2) University grant 60/2009: A tumor suppressor gene hypermethylation as a new marker for early diagnosis of ovarian cancer - cont.
- Roman Fiolka, M.D.
1) University grant 61/2009: A tumor suppressor gene hypermethylation as a marker for early diagnosis of endometrial cancer.
2) University grant 576/2010: A tumor suppressor gene hypermethylation as a marker for early diagnosis of endometrial cancer - cont.
- Ivana Kapustová, M.D.
1) University grant 172/2010: Analysis of pro-apoptotic genetic changes as a biological marker profile and risk of breast cancer.
2) University grant 450/2011: Analysis of pro-apoptotic genetic changes as a biological marker profile and risk of breast cancer (cont.)
3) University grant 559/2012: Analysis of pro-apoptotic genetic changes as a biological marker profile and risk of breast cancer (cont.)
- Petra Móricová, M.D.
1) University grant 243/2012: Prediction of breast tumor development by the assessment of growth stimulating and apoptosis related genes in breast tissue.
- Iveta Švecová, M.D.
1) University grant 381/2010: Use of fetal DNA in maternal blood in the prenatal diagnosis of fetal pathology.
- Veronika Janušicová, MSc.
1) University grant 71/2010: Detection of nucleic acids and expression of human papillomavirus in cervical cancer prevention.
2) University grant 103/2011: Evaluation of the expression of papillomaviruses and markers of carcinogenesis in cervical cells
- Eva Ježková, MSc.
1) University grant 156/2010: Hypermethylation of genes PITX2 and RASSF1A in prevention, diagnosis and prognosis in patients with carcinoma of the mammary gland.
- Petra Šumichrastová, M.D.
1) University grant 468/2011: The impact of smoking on the female body in terms of breast carcinogenesis
2) University grant 372/2012: The impact of smoking on the female body in terms of breast carcinogenesis (cont.)
- Jana Siváková, M.D.
1) University grant 406/2011: Diagnostics of malformations by ultrasonography during the first trimester
2) University grant 306/2012: Diagnostics of malformations by ultrasonography during the first trimester (cont.)
- Miroslav Haško, M.D.
1) University grant 230/2011: Appropriate combination of biochemical, genetic and Doppler ultrasound markers in early prediction of preeclampsia.
- Erik Kúdela, M.D.
1) University grant 242/2012: Detection of TERC gene amplification by the FISH as a novel diagnostic tool of dysplasia in cervical cells
c) Allocated grants - current state + principal investigator:
Grant VEGA 1/0243/12 Assoc. prof. Pavol Žúbor, M.D., PhD.
„Profile analysis of gene expresion of breast cancer for evaluation of risk of breast cancer and personalised treatment.“
Grant VEGA: 1/0271/12 Assoc. prof. Jozef Višňovský, M.D., PhD.
„Detection of amplification of gen TERC /3q26/ in cytological samples of precancerosis and cervical cancer “
Grant VEGA: 1/0283/12 Assoc. prof. Kamil Biringer, M.D., PhD.
„Genomic and genetic polymorfism in etiopatogenesis of urinal inkontinency and pelvic bottom disorders.“
d) International cooperation:
Clinic is not projectly incorporated into international cooperation with universities and clinical departments.
The most important results:
- Clinic has national priority in postpartal anemy treatment with EPO.
- Clinic has national priority in diagnostic of changes in hepatal circulation in gravidity.
- Clinic has national priority in detection of genetical changes leading to increasing risk of breast cancer and corporal cancer.
Emplyoees of clinic achieved many awards in research and medicine.
The most important:
– Award of slovak medical society
– International award firm Schering
– Austrian the best article award prof. Slunský
– Award of Zurich University
– Ambrova award
– Guothova award
– Cristal wing award 2003
– Gold medail of Comenius University
– Gold medail SLS
– Bronze medail J.E. Purkyňe
Others important scientific activities :
Clinic was seatle of editorial board and scientific publishers Slovak obstetrics and gynecology
The head of the clinic is a regional specialist for gynecology and obstetrics, a member of editorial boards of four journals:
- Gynekológ (zahraničné ČR)
- Česká gynekológia a pôrodníctvo (zahraničné ČR)
- Slovenská gynekológia a pôrodníctvo
- Acta Medica Martiniana
The most important measure of the level of scientific work is the elected head of the department chairman of committee for postgraduate study in obstetrics and gynecology SR.
prof. Jan Danko, M.D., PhD. is member of:
- World Society for sonography in obstetrics and gynecology
- Committee of the Slovak Gynaecological and Obstetrical Society (president)
- Scientific Board of Comenius University (Dean)
- Scientific Board of UPJŠ Košice LF Bratislava, LF Olomouc
- Chairman of the Scientific Council of the National Library
- Karol Dókuš, M.D., PhD is an expert reviewer for the journal: American Journal of Obstetrics and Gynecology, International Journal of Gynecology and Obstetrics
- assoc. prof. Pavol Žúbor, M.D., PhD. is an expert reviewer for the CC journal:
Cell Proliferation, Acta Pathologica Microbiologica et Imunologica Scandinavica, Histopathology Experimental and Molecular Pathology Cancer Therapy, Cancer Letters,Molecular Biology Reports,International Journal of Gynecological Cancer,Archives of Gynecology and Obstetrics,Annals of Saudi Medicine, Cancer Detection and Prevention,The Journal of Medical Case Reports, Acta Medica Martiniana,Oncology, BMC Cancer, International Journal of Biomedical Science
is an expert reviewer for the journal(Sentinel reader for Evidence-Based medicine) pre (MORE) system na McMaster University
McMaster Online Rating of Evidence (MORE)
Health Information Research Unit
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Member of editorial boards of two journals:
- Journal of Cancer Science and Therapy (foreign USA)
- Acta Medica Martiniana (SR)
Membership in international / global professional societies:
- International Society of Ultrasound in Obstetrics and Gynecology , prof. Jan Danko, M.D., PhD.
- The FetalMedicineFoundation (FMF), Karol Dókuš, M.D., PhD.
- European Society of Gynecological Oncology (ESGO): assoc. prof. Pavol Žúbor, M.D., PhD.
- Interventional Oncology Society (IOS): assoc. prof. Pavol Žúbor, M.D., PhD.
- European Cervical Cancer Association (ECCA): assoc. prof. Pavol Žúbor, M.D., PhD.
- European Society of Breast Cancer Specialists (EUSOMA): assoc. prof. Pavol Žúbor, M.D., PhD.
- Guidepoint Global Advisors (Guidepoint Global, LLC): assoc. prof. Pavol Žúbor, M.D., PhD.
- European Board and College of the Obstetrics and Gynecology (EBCOG): prof. Jan Danko, M.D., PhD., assoc. prof. Pavol Žúbor, M.D., PhD.
Organisation of scientific events:
3.- 4. 9. 1998 – national scientific conference SGPS „ Prevention in gynecology and obstetrics “
coordinator of conference: prof. Jan Danko, M.D., PhD.
30. 5. – 1. 6. 2002 – IX. a national scientific conference SGPS SLS with international participation
president of congres: prof. Jan Danko, M.D., PhD.
30. 9. – 2. 10. 2010 – XVII. a national scientific conference SGPS SLS with international participation
president of congres: prof. Jan Danko, M.D., PhD.
congres 3rd Central-Eastern European Symposium on Free Nucleic Acids in Non-Invasive Prenatal Diagnosis 4/2014, Martin, SK
president of congres: prof. MUDr. Ján Danko, PhD.
Department organized 16 smaller specialized symposia.