Jessenius Faculty of Medicine
in Martin
Comenius University in Bratislava

Department of Experimental Respirology

Head of department: Assoc. Prof. Daniela Mokrá, M.D., PhD.

 

Laboratory of Experimental Pharmacology

Head of laboratory: Assoc. Prof. RNDr. Soňa Fraňová, PhD.

This laboratory studies effects of pharmacological substances on the respiratory tract defense mechanisms in models of chro­nic respiratory diseases (chronic obstructive pulmonary disease -COPD, allergic asthma, ciliary dyskinesia, lung fibrosis). In the models are studied changes in airway defense mechanisms, mucociliary clearance, cough and bronchoconstriction. Labora­tory of Experimental Pharmacology is able to comprehensively assess the sensitivity and effectiveness of the defense mechanisms as well as­ their changes in correlation with the degree of ongoing inflammation, hypertrophy and apoptosis.

 

Laboratory of Experimental Physiology

Head of laboratory: Assoc. Prof. Daniela Mokrá, M.D., PhD.

The aim of the laboratory is to prepare and implement a variety of experimental models of acute and chronic respiratory diseases and in comprehensive way to study the effect of using treatments for respiratory, cardiovascular and inflammatory parameters.  Currently, there are used animal experiments - models of meconium aspiration syndrome (MAS) and neonatal acute lung injury (ALI / ARDS) induced by intratracheal human meconium application and by repeated lung lavage with saline. The clinical pictures of these models recall MAS and  respiratory distress syndrome of premature infants (RDS).

 

Laboratory for Surfactant Research

Head of laboratory: Prof. Andrea Čalkovská, M.D., DSc.

Research work in these laboratories is focused on mode­ling of  acute lung injury and dysfunction of the pulmonary sur­factant – the fluid lining inner surface of the pulmonary alveoli. The main goal is to understand the physiological and pathophys­iological processes of the injury and dysfunction and to improve diagnosis and treatment of the serious respiratory problems. In addition to evaluation of surfactant activity in samples of the BAL fluid and in exogenous surfactants, in these laboratories are measured surfactant proteins in BAL fluid and/or in plasma, where their abnormal levels can indicate lung damage.