Department of Experimental Respirology
Head of department: Assoc. Prof. Daniela Mokrá, M.D., PhD.
Laboratory of Experimental Pharmacology
Head of laboratory: Assoc. Prof. RNDr. Soňa Fraňová, PhD.
This laboratory studies effects of pharmacological substances on the respiratory tract defense mechanisms in models of chronic respiratory diseases (chronic obstructive pulmonary disease -COPD, allergic asthma, ciliary dyskinesia, lung fibrosis). In the models are studied changes in airway defense mechanisms, mucociliary clearance, cough and bronchoconstriction. Laboratory of Experimental Pharmacology is able to comprehensively assess the sensitivity and effectiveness of the defense mechanisms as well as their changes in correlation with the degree of ongoing inflammation, hypertrophy and apoptosis.
Laboratory of Experimental Physiology
Head of laboratory: Assoc. Prof. Daniela Mokrá, M.D., PhD.
The aim of the laboratory is to prepare and implement a variety of experimental models of acute and chronic respiratory diseases and in comprehensive way to study the effect of using treatments for respiratory, cardiovascular and inflammatory parameters. Currently, there are used animal experiments - models of meconium aspiration syndrome (MAS) and neonatal acute lung injury (ALI / ARDS) induced by intratracheal human meconium application and by repeated lung lavage with saline. The clinical pictures of these models recall MAS and respiratory distress syndrome of premature infants (RDS).
Laboratory for Surfactant Research
Head of laboratory: Prof. Andrea Čalkovská, M.D., DSc.
Research work in these laboratories is focused on modeling of acute lung injury and dysfunction of the pulmonary surfactant – the fluid lining inner surface of the pulmonary alveoli. The main goal is to understand the physiological and pathophysiological processes of the injury and dysfunction and to improve diagnosis and treatment of the serious respiratory problems. In addition to evaluation of surfactant activity in samples of the BAL fluid and in exogenous surfactants, in these laboratories are measured surfactant proteins in BAL fluid and/or in plasma, where their abnormal levels can indicate lung damage.