Department of Clinical Respirology
Head of department: Assoc. Prof. Juraj Mokrý, M.D., PhD.
Laboratory of Clinical Pharmacology and Toxicology
Head of laboratory: Assoc. Prof. Juraj Mokrý, M.D., PhD.
This laboratory concentrates research on the pharmacokinetics and drug metabolism as well as on determination of toxic substances. The laboratory extends the research in Respirology, but also in other disciplines, focusing on the analysis of biological samples and drug levels and their metabolites. This opens a space for interdisciplinary collaboration with other departments and clinics. Laboratory pharmacokinetics and toxicology is also directed to the development of novel methods enabling the detection of substances at low concentrations for the purpose of monitoring the pharmacokinetics of drugs applied using modern and sensitive analytical methods (e.g. liquid and gas chromatography combined with mass spectrometry).
Laboratory for Coughing Research
Head of laboratory: Assoc. Prof. Renata Péčová, M.D., PhD.
Mechanisms of cough reflex regulation contain a number of interactions of numerous afferent nerve terminals, pathways and central structures. Laboratory for coughing research focuses on the detailed analysis of the sensory pathways of coughing to identify future therapeutic approaches for the efficient treatment of diseases accompanied by chronic cough.
In addition to investigation of the cough reflex sensitivity, in perspective is monitoring neural activity in vital human biopsies using functional imaging. For this purpose is available set for nerve cell activity in vital human biopsies on the basis of functional imaging. The aim of the laboratory work is to develop new high-quality diagnostic algorithm to determine the specific mechanisms of chronic cough in a particular patient especially with bronchial asthma, allergic rhinitis, gastroesophageal reflux and introduce a personalized therapy with the possibility of monitoring the effect of treatment with 24-hour monitoring of cough.
Research work of the Division of Respirology is concentrated on the needs of practice. We believe that the intensive research of this division will accelerate the acquisition of important knowledge in this field and thus in a very short time it will contribute to the reduction of morbidity and mortality due to respiratory diseases.