Jessenius Faculty of Medicine
in Martin
Comenius University in Bratislava

Department of neurosciences in pathophysiology

 

Head of department: MSc. Alžbeta Trančíková, PhD.

Department includes 3 laboratories focused on the study of mechanisms of hypersensitivity and hyperactivity of visceral nerves of patients suffering from visceral pain followed by identification and preclinical validation of target molecules aimed for development of new drugs. In addition, laboratories are focused on the study of structure-function coupling in nerve terminals of visceral nerves mediating pain (visceral nociceptors) and the changes associated with different diseases, the role of TRP and ASIC receptors, voltage gated sodium channels (NaV) and other ion channels in visceral hypersensitivity associated with different diseases as well as afferent mechanisms cough hypersensitivity associated with chronic and post-infection cough.

 

Laboratory of visceral pain

 

Head of laboratory: MSc. Alžbeta Trančíková, PhD.

Laboratory is focused on the study of role of vagal nerves in visceral pain via monitoring of functional imaging of nerves in tissues, study of structure-function coupling in nerve terminals of visceral nociceptors and their activity in tissues, functional imaging of membrane potentials of visceral nerves using voltage-dependent indicators using multiphoton microscope Axio Examiner Z1 with confocal unit LSM 880.

Fig. 2. Multiphoton microscope (A), imaging of visceral nerve terminals in oesophagus of guinea pig (B)

 

Laboratory of neural hyperactivity

 

Head of laboratory: Assoc. Prof. RNDr. Mariana Brozmanová, PhD.

Laboratory is using methods of electrophysiology to study functions of different types of ionic channels and their changes associated with visceral hypersensitivity as a consequence of different diseases.

 

Laboratory of regulation of cough reflex

 

Head of laboratory: Prof. Miloš Tatár, M.D., PhD.

Laboratory is focused on experimental and clinical study of pathophysiology and pharmacology of cough reflex associated with upper airways inflammation.