Department of experimental biochemistry
Head of department: Prof. RNDr. Peter Kaplán, PhD.
Department is focused on study of molecular mechanisms of heart and brain ageing as well as mechanisms of ischemia-reperfusion injury of heart and brain, study of molecular mechanisms of ischemia-induced neuronal cell death, identification of target proteins playing a role in protection of neuronal cells from ischemia-reperfusion injury.
Department is using imaging mass spectrometer IMScope TRIO for identification of metabolites and study of metabolite modifications in tissues as a consequence of pathologic processes of CNS, pharmacokinetic analysis of therapeutic drugs, localization of native drugs and their metabolites in tissues. In addition, mass spectrometer Iontrap-TOF is used for identification of proteins and their posttranslation modifications as a consequence of aging and ischemia.